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KMID : 0387420070180020101
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Korean Society of Oriental Neuropsychiatry
2007 Volume.18 No. 2 p.101 ~ p.132
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The Effects of NogYongDaeBoTang,(NYDBT)on the Alzheimer’s Disease Model Induced by CT-105 and $A{\beta}$
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Seo Gyoo-Tae
Lee Eun-Kyung
Choi Chyung-Hong
Chung Dae-Kyoo
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Abstract
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Objective:This research investigates the effect of the NogYongDaeBoTang,(NYDBT) on Alzheimer’s disease.
Method:The effects of the NYDBT extract on (1) $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ mRNA of PC-12 cells treated with LPS; (2) acetylcholinesterase(AChE), amyloid precursor proteins(APP), and glial fibrillary acidic protein(GFAP) mRNA the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of $IL-1{\beta}$, $TNF-{\alpha}$, MDA, $IL-1{\beta}$ mRNA, and $TNF-{\alpha}$ mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer‘s diseased mice induced with ${\beta}A$ were investigated.
Results: 1. The NYDBT extract suppressed the expression of $IL-1{\beta}$, IL-6 and $TNF-{\alpha}$ mRNA in BV2 microglia cell line treated with LPS. 2. The NYDBT extract suppressed the expression of $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ protein production in BV2 microglia cell line treated with LPS. 3. For the NYDBT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer’s disease induced by $A{\beta}$ in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The NYDBT extract suppressed the over-expression of $IL-1{\beta}$ protein, $TNF-{\alpha}$ protein, MDA, and CD68/CD11b, in the mice with Alzheimer’s disease induced by $A{\beta}$. 5. The NYDBT extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer’s disease induced by $A{\beta}$. 6. The NYDBT extract reduced the Tau protein, GFAP protein, and presenilin1/2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer’s disease induced by $A{\beta}$.
Conclusion:These results suggest that the NYDBT extract may be effective for the prevention and treatment of Alzheimer’s disease.
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KEYWORD
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NogYongDaeBoTang, (NYDBT), Alzheimer’s disease, CT105, Cytokine
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